4-Fluorobenzenesulfonyl chloride → HCID 178527583, compound

HRID 2042447Notes

Reaction equation

HRID 2042447 reaction equation
Cl.Cl.Cl.[O:4]1[C:12]2[CH:11]=[CH:10][N:9]=[C:8]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[CH2:6][CH2:5]1.[F:28][C:29]1[CH:34]=[CH:33][C:32]([S:35](Cl)(=[O:37])=[O:36])=[CH:31][CH:30]=1>>[O:4]1[C:12]2[CH:11]=[CH:10][N:9]=[C:8]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][S:35]([C:32]5[CH:33]=[CH:34][C:29]([F:28])=[CH:30][CH:31]=5)(=[O:37])=[O:36])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 95884-Fluorobenzenesulfonyl chlorideHCID 178478589HCID 178478589, compound2×

Product 1

HCID 178527583HCID 178527583, compound

Procedure

The title compound, light yellow solid (109 mg, 89%), MS (ISP) m/z=489.4 [(M+H)+], mp 221° C., was prepared in accordance with the general method of example 48 from trans-4-{2-[4-(2,3-dihydrofuro[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexanamine trihydrochloride (intermediate C) (110 mg, 0.25 mmol) and 4-fluoro-benzene-1-sulfonyl chloride.

Sources & evidence

ORD record
ord-64af9ad9471b45f89f2c1b7c6628f464
Source dataset
uspto-grants-2013_11
Patent number
US08586579B2

Reaction notes

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