4-Fluorobenzenesulfonyl chloride → HCID 178527583, compound

Participants

Reaction Steps

The title compound, light yellow solid (109 mg, 89%), MS (ISP) m/z=489.4 [(M+H)+], mp 221° C., was prepared in accordance with the general method of example 48 from trans-4-{2-[4-(2,3-dihydrofuro[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexanamine trihydrochloride (intermediate C) (110 mg, 0.25 mmol) and 4-fluoro-benzene-1-sulfonyl chloride.

Provenance & Evidence