Cyanoacetic acid → HCID 178511192, compound

HRID 2042454Notes

Reaction equation

HRID 2042454 reaction equation
Cl.Cl.Cl.[O:4]1[C:12]2[CH:11]=[CH:10][N:9]=[C:8]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[CH2:6][CH2:5]1.[C:28]([CH2:30][C:31](O)=[O:32])#[N:29]>>[C:28]([CH2:30][C:31]([NH:27][C@H:24]1[CH2:25][CH2:26][C@H:21]([CH2:20][CH2:19][N:16]2[CH2:17][CH2:18][N:13]([C:8]3[C:7]4[CH2:6][CH2:5][O:4][C:12]=4[CH:11]=[CH:10][N:9]=3)[CH2:14][CH2:15]2)[CH2:22][CH2:23]1)=[O:32])#[N:29]

Participants

3

Reactant 2

HCID 9740Cyanoacetic acidHCID 178478589HCID 178478589, compound2×

Product 1

HCID 178511192HCID 178511192, compound

Procedure

The title compound, off-white solid (86 mg, 87%), MS (ISP) m/z=398.3 [(M+H)+], mp 188° C., was prepared in accordance with the general method of example 32 from trans-4-{2-[4-(2,3-dihydrofuro[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexanamine trihydrochloride (intermediate C) (110 mg, 0.25 mmol) and cyano-acetic acid.

Sources & evidence

ORD record
ord-2cb2af2920064a948d62d7a6c91a7248
Source dataset
uspto-grants-2013_11
Patent number
US08586579B2

Reaction notes

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