Acetic Acid → HCID 178474982, compound

HRID 2042491Notes

Reaction equation

HRID 2042491 reaction equation
[O:1]1[C:9]2[CH:8]=[CH:7][N:6]=[C:5]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C@H:18]4[CH2:23][CH2:22][C@H:21]([NH:24][C:25](=[O:30])[CH2:26]/C=C/C)[CH2:20][CH2:19]4)[CH2:12][CH2:11]3)[C:4]=2[CH2:3][CH2:2]1.[C:31](O)(=O)C>>[CH3:31][C:7]1[N:6]=[C:5]([N:10]2[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][C@H:18]3[CH2:19][CH2:20][C@H:21]([NH:24][C:25](=[O:30])[CH3:26])[CH2:22][CH2:23]3)[CH2:14][CH2:15]2)[C:4]2[CH2:3][CH2:2][O:1][C:9]=2[CH:8]=1

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 178447389HCID 178447389, compound2×

Product 1

HCID 178474982HCID 178474982, compound

Procedure

The title compound, white solid (96 mg, 83%), MS (ISP) m/z=387.4 [(M+H)+], mp 217.5° C., was prepared in accordance with the general method of example 32 from trans-4-{2-[4-(6-methyl-2,3-dihydro-furo[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexylamine trihydrochloride (intermediate E) (136 mg, 0.3 mmol) and acetic acid.

Sources & evidence

ORD record
ord-d6db5e0b51a340f5826efb72b252326e
Source dataset
uspto-grants-2013_11
Patent number
US08586579B2

Reaction notes

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