Tetrahydropyran-4-ylacetic acid → HCID 178430614, compound

HRID 2042498Notes

Reaction equation

HRID 2042498 reaction equation
Cl.Cl.Cl.[CH3:4][C:5]1[C:6]2[O:28][CH2:27][CH2:26][C:7]=2[C:8]([N:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]3[CH2:24][CH2:23][C@H:22]([NH2:25])[CH2:21][CH2:20]3)[CH2:13][CH2:12]2)=[N:9][CH:10]=1.[O:29]1[CH2:34][CH2:33][CH:32]([CH2:35][C:36](O)=[O:37])[CH2:31][CH2:30]1>>[CH3:4][C:5]1[C:6]2[O:28][CH2:27][CH2:26][C:7]=2[C:8]([N:11]2[CH2:12][CH2:13][N:14]([CH2:17][CH2:18][C@H:19]3[CH2:20][CH2:21][C@H:22]([NH:25][C:36](=[O:37])[CH2:35][CH:32]4[CH2:33][CH2:34][O:29][CH2:30][CH2:31]4)[CH2:23][CH2:24]3)[CH2:15][CH2:16]2)=[N:9][CH:10]=1

Participants

3

Reactant 2

HCID 2773575Tetrahydropyran-4-ylacetic acidHCID 178430610HCID 178430610, compound2×

Product 1

HCID 178430614HCID 178430614, compound

Procedure

The title compound, white solid (52 mg, 74%), MS (ISP) m/z=471.6 [(M+H)+], mp 199° C., was prepared in accordance with the general method of example 32 from trans-4-{2-[4-(7-methyl-2,3-dihydro-furo[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexylamine trihydrochloride (intermediate G) (68.1 mg, 0.15 mmol) and tetrahydropyran-4-yl-acetic acid.

Sources & evidence

ORD record
ord-30e4219d62cf4fd9bcbb84a6cc5b6230
Source dataset
uspto-grants-2013_11
Patent number
US08586579B2

Reaction notes

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