6-Morpholinonicotinic Acid → HCID 178523706, compound

HRID 2042507Notes

Reaction equation

HRID 2042507 reaction equation
Cl.Cl.Cl.[O:4]1[C:12]2[CH:11]=[CH:10][N:9]=[C:8]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[CH2:6][CH2:5]1.[N:28]1([C:34]2[CH:42]=[CH:41][C:37]([C:38](O)=[O:39])=[CH:36][N:35]=2)[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1>>[O:4]1[C:12]2[CH:11]=[CH:10][N:9]=[C:8]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:38](=[O:39])[C:37]5[CH:41]=[CH:42][C:34]([N:28]6[CH2:29][CH2:30][O:31][CH2:32][CH2:33]6)=[N:35][CH:36]=5)[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 27764606-Morpholinonicotinic AcidHCID 178478589HCID 178478589, compound2×

Product 1

HCID 178523706HCID 178523706, compound

Procedure

The title compound, white solid (108 mg, 83%), MS (ISP) m/z=521.5 [(M+H)+], mp 222° C., was prepared in accordance with the general method of example 32 from trans-4-{2-[4-(2,3-dihydrofuro[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexanamine trihydrochloride (intermediate C) (110 mg, 0.25 mmol) and 6-morpholin-4-yl-nicotinic acid.

Sources & evidence

ORD record
ord-46561fb5d737493d8807d7620601a32b
Source dataset
uspto-grants-2013_11
Patent number
US08586579B2

Reaction notes

Loading…