Piperidine → 2-Methyl-5-[4-(3-piperidin-1-yl-propoxy)-phenyl]-2H-pyridazin-3-one

HRID 2042558Notes

Reaction equation

HRID 2042558 reaction equation
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[N:16][N:15]([CH3:18])[C:14](=[O:19])[CH:13]=2)=[CH:8][CH:7]=1.[NH:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1>>[CH3:18][N:15]1[C:14](=[O:19])[CH:13]=[C:12]([C:9]2[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH2:3][CH2:2][N:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)=[CH:7][CH:8]=2)[CH:17]=[N:16]1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 569463035-[4-(3-chloropropoxy)-phenyl]-2-methyl-2H-pyridazin-3-one

Product 1

HCID 249959952-Methyl-5-[4-(3-piperidin-1-yl-propoxy)-phenyl]-2H-pyridazin-3-one

Procedure

This compound was prepared as the hydrochloride salt using 5-[4-(3-chloropropoxy)-phenyl]-2-methyl-2H-pyridazin-3-one and piperidine using the procedure described in Example 91 Step 5; Mp 253-4° C.; MS m/z 328 (M+H).

Sources & evidence

ORD record
ord-2b04ecf281104e5f9cb6274356b34dc1
Source dataset
uspto-grants-2013_11
Patent number
US08586588B2

Reaction notes

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