1H-Azepine → 5-[4-(3-Azepan-1-yl-propoxy)-phenyl]-2-methyl-2H-pyridazin-3-one

HRID 2042559Notes

Reaction equation

HRID 2042559 reaction equation
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[N:16][N:15]([CH3:18])[C:14](=[O:19])[CH:13]=2)=[CH:8][CH:7]=1.[NH:20]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=[CH:21]1>>[N:20]1([CH2:2][CH2:3][CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([C:12]3[CH:17]=[N:16][N:15]([CH3:18])[C:14](=[O:19])[CH:13]=3)=[CH:8][CH:7]=2)[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 64514761H-AzepineHCID 569463035-[4-(3-chloropropoxy)-phenyl]-2-methyl-2H-pyridazin-3-one

Product 1

HCID 249959965-[4-(3-Azepan-1-yl-propoxy)-phenyl]-2-methyl-2H-pyridazin-3-one

Procedure

This compound was prepared as the hydrochloride salt using 5-[4-(3-chloropropoxy)-phenyl]-2-methyl-2H-pyridazin-3-one and azepine using the procedure described in Example 91 Step 5; Mp 247-8° C.; MS m/z 342 (M+H).

Sources & evidence

ORD record
ord-428058c0a6a9450984ebff7a82f97faa
Source dataset
uspto-grants-2013_11
Patent number
US08586588B2

Reaction notes

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