Hydrazine hydrate (1:1) → HCID 56946197, compound

HRID 2042562Notes

Reaction equation

HRID 2042562 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:16](O)[O:15][C:14](=O)[CH:13]=2)=[CH:8][CH:7]=1.O.[NH2:20][NH2:21]>CCO>[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:16]=[N:21][NH:20][C:14](=[O:15])[CH:13]=2)=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 56946194HCID 56946194, compound

Product 1

HCID 56946197HCID 56946197, compoundYield 61%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of the product from example 94 step 3 (2.0 g, 7.45 mmol) and hydrazine hydrate (0.59 g, 1.5 eq.) in 20 mL of EtOH was stirred at 85° C. for 2 h. The solvent was reduced and the solid was collected and washed with cold EtOH to give 1.2 g (61%) of 5-[4-(3-chloropropoxy)phenyl)-2H-pyridazin-3-one: Mp 197-9° C.; MS m/z 265 (M+H).

Workup

  1. customthe solid was collected
  2. washwashed with cold EtOH

Sources & evidence

ORD record
ord-cb8cf8fc7cad4f81b7936a0e3d52b526
Source dataset
uspto-grants-2013_11
Patent number
US08586588B2

Reaction notes

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