反应详情

温度

70 °C

To 2-(4-hydroxy-benzoyl)-cyclobutanecarboxylic acid ethyl ester (0.55 g, 2.20 mmol) in acetone (10 mL) was added potassium carbonate (0.91 g, 6.58 mmol) and 1-bromo-chloropropane (0.26 mL, 2.63 mmol). After overnight stirring at 70° C., the reaction was filtered, partitioned between dichloromethane/water, washed with brine, dried over sodium sulfate, and concentrated. The product was purified using a Single Step column (9:1 hexanes:ethyl acetate) to obtain 0.30 g (42%); MS m/z 325 (M+H).

1. filtrationthe reaction was filtered
2. custompartitioned between dichloromethane/water
3. washwashed with brine
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated
6. customThe product was purified
7. customto obtain 0.30 g (42%)