Trifluoroacetic acid → HCID 58223092, compound

HRID 2042697Notes

Reaction equation

HRID 2042697 reaction equation
[F:1][C:2]([F:36])([F:35])[CH2:3][O:4][C:5]1[N:10]=[C:9]([NH:11][C:12]2[CH:20]=[CH:19][C:15]([C:16]([O-:18])=[O:17])=[CH:14][CH:13]=2)[N:8]=[C:7]([NH:21][C:22]2[CH:34]=[CH:33][C:25]([C:26]([O:28]C(C)(C)C)=[O:27])=[CH:24][CH:23]=2)[N:6]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:36][C:2]([F:1])([F:35])[CH2:3][O:4][C:5]1[N:6]=[C:7]([NH:21][C:22]2[CH:23]=[CH:24][C:25]([C:26]([OH:28])=[O:27])=[CH:33][CH:34]=2)[N:8]=[C:9]([NH:11][C:12]2[CH:20]=[CH:19][C:15]([C:16]([OH:18])=[O:17])=[CH:14][CH:13]=2)[N:10]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86652470HCID 86652470, compound

Product 1

HCID 58223092HCID 58223092, compoundYield 22%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of crude tert-butyl 4,4′-(6-(2,2,2-trifluoroethoxy)-1,3,5-triazine-2,4-diyl)bis(azanediyl)dibenzoate (562 mg) in CH2Cl2 (10 mL) was added TFA (3 mL). The mixture was stirred at room temperature for 16 hours. All solvents were removed under vacuum. The residue was purified by preparative HPLC to give 4,4′-(6-(2,2,2-trifluoroethoxy)-1,3,5-triazine-2,4-diyl)bis(azanediyl)dibenzoic acid (110 mg).

Workup

  1. customAll solvents were removed under vacuum
  2. customThe residue was purified by preparative HPLC

Sources & evidence

ORD record
ord-7747a298dc484b4b9f5e1b9ec5a001ea
Source dataset
uspto-grants-2013_11
Patent number
US08586584B2

Reaction notes

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