Dimethylethylamine → HCID 53253205, compound

HRID 2042773Notes

Reaction equation

HRID 2042773 reaction equation
C[O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[CH2:11][C@H:10]([N:13]([CH2:21][CH2:22][CH3:23])[CH2:14][CH2:15][C:16]1[S:17][CH:18]=[CH:19][CH:20]=1)[CH2:9][CH2:8]2.CN(C)CC>CCCCCC.C(OCC)(=O)C>[OH:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[CH2:11][C@H:10]([N:13]([CH2:21][CH2:22][CH3:23])[CH2:14][CH2:15][C:16]1[S:17][CH:18]=[CH:19][CH:20]=1)[CH2:9][CH2:8]2

Participants

4

Reactant 2

HCID 11723DimethylethylamineHCID 53252573HCID 53252573, compound

Product 1

HCID 53253205HCID 53253205, compound

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Synthesis worked according to the preparation of A7-1 when using 21 mg (0.06 mmol) (R)—N-(8-methoxytetralin-2-yl)-N-propyl-N-[2-(2-thienyl)ethyl]amine ((R)-A5-1: R═OMe, Cy=2-thienyl). Flash chromatography was done using hexane/ethyl acetate 40/10 in the presence of 0.5% (v/v) dimethylethylamine to achieve compound 1a.

Workup

  1. customSynthesis
  2. customworked according to the preparation of A7-1 when

Sources & evidence

ORD record
ord-573448eb4d2c48b1a0dce64e027d6293
Source dataset
uspto-grants-2013_11
Patent number
US08586603B2

Reaction notes

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