8-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine → N-(2-Benzo[b]thienylethyl)-N-(8-methoxytetralin-2-yl)-N-propylamine

HRID 2042775Notes

Reaction equation

HRID 2042775 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[CH2:11][CH:10]([NH:13][CH2:14][CH2:15][CH3:16])[CH2:9][CH2:8]2.[S:17]1[C:21]([CH2:22][C:23](O)=O)=[CH:20][C:19]2[CH:26]=[CH:27][CH:28]=[CH:29][C:18]1=2>>[S:17]1[C:21]([CH2:22][CH2:23][N:13]([CH:10]2[CH2:9][CH2:8][C:7]3[C:12](=[C:3]([O:2][CH3:1])[CH:4]=[CH:5][CH:6]=3)[CH2:11]2)[CH2:14][CH2:15][CH3:16])=[CH:20][C:19]2[CH:26]=[CH:27][CH:28]=[CH:29][C:18]1=2

Participants

3

Reactant 2

HCID 127414178-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amineHCID 127650652-(1-Benzothiophen-2-yl)acetic acid

Product 1

HCID 67252230N-(2-Benzo[b]thienylethyl)-N-(8-methoxytetralin-2-yl)-N-propylamine

Procedure

Synthesis works according to the preparation of A4-1 or A4-4 when using N-(8-methoxytetralin-2-yl)-N-propylamine (A2-1: R═OMe) and 2-benzo[b]thienyl acetic acid (A3-10: R═OMe, Cy=2-benzo[b]thienyl) (purchasable from Rare Chemicals, Kiel (Germany); order number: GT HW 0344) and subsequent reaction according to the synthesis of A5-1.

Workup

  1. customSynthesis
  2. customworks according to the preparation of A4-1 or A4-4 when
  3. customaccording to the synthesis of A5-1

Sources & evidence

ORD record
ord-5b07ce2d562a4cbbbae31e8b7cde5637
Source dataset
uspto-grants-2013_11
Patent number
US08586603B2

Reaction notes

Loading…