Benzo[b]thiophene-3-acetic acid → N-(3-Benzo[b]thienylethyl)-N-(8-methoxytetralin-2-yl)-N-propylamine

HRID 2042776Notes

Reaction equation

HRID 2042776 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[CH2:11][CH:10]([NH:13][CH2:14][CH2:15][CH3:16])[CH2:9][CH2:8]2.[S:17]1[CH:21]=[C:20]([CH2:22][C:23](O)=O)[C:19]2[CH:26]=[CH:27][CH:28]=[CH:29][C:18]1=2>>[S:17]1[CH:21]=[C:20]([CH2:22][CH2:23][N:13]([CH:10]2[CH2:9][CH2:8][C:7]3[C:12](=[C:3]([O:2][CH3:1])[CH:4]=[CH:5][CH:6]=3)[CH2:11]2)[CH2:14][CH2:15][CH3:16])[C:19]2[CH:26]=[CH:27][CH:28]=[CH:29][C:18]1=2

Participants

3

Reactant 2

HCID 70799Benzo[b]thiophene-3-acetic acidHCID 127414178-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine

Product 1

HCID 67250552N-(3-Benzo[b]thienylethyl)-N-(8-methoxytetralin-2-yl)-N-propylamine

Procedure

Synthesis works according to the preparation of A4-1 or A4-4 when using N-(8-methoxytetralin-2-yl)-N-propylamine (A2-1: R═OMe) and 3-benzo[b]thienyl acetic acid (A3-11: R═OMe, Cy=3-benzo[b]thienyl) (purchasable from Alfa Aesar, Karlsruhe (Germany); order number: LO 5855 or Maybridge, Tintagel, Cornwall (UK); order number: S11080) and subsequent reaction according to the synthesis of A5-1.

Workup

  1. customSynthesis
  2. customworks according to the preparation of A4-1 or A4-4 when
  3. customaccording to the synthesis of A5-1

Sources & evidence

ORD record
ord-3a2d3a0c18644197992207d9724f0f62
Source dataset
uspto-grants-2013_11
Patent number
US08586603B2

Reaction notes

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