反应详情

A mixture of N-(3-nitro-2,4-dimethyl-benzyl)-2,2,2-trifluoroacetamide (1.53 g, 5.54 mmol), 4M NaOH-solution (6.9 mL, 28 mmol) and MeOH (30 mL) is refluxed for 2 h. Then the mixture is concentrated, diluted with water and extracted with EtOAc. The organic phase is dried with Na2SO4, filtered and concentrated.

1. temperatureis refluxed for 2 h
2. concentrationThen the mixture is concentrated
3. additiondiluted with water
4. extractionextracted with EtOAc
5. dry with materialThe organic phase is dried with Na2SO4
6. filtrationfiltered
7. concentrationconcentrated