HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 3-Nitro-2,4-dimethyl-benzylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | N-(3-Nitro-2,4-dimethyl-benzyl)-2,2,2-trifluoroacetamide | HCID 56840191 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Nitro-2,4-dimethyl-benzylamine | HCID 56839972 | — |
Reaction Steps
A mixture of N-(3-nitro-2,4-dimethyl-benzyl)-2,2,2-trifluoroacetamide (1.53 g, 5.54 mmol), 4M NaOH-solution (6.9 mL, 28 mmol) and MeOH (30 mL) is refluxed for 2 h. Then the mixture is concentrated, diluted with water and extracted with EtOAc. The organic phase is dried with Na2SO4, filtered and concentrated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586604B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-6d1baf858ea74d8c8a1442eea1d634b1 |
| Source note | uspto-grants-2013_11 |