HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pivaloyl chloride → N-(4-Chloro-3-nitrobenzyl)-2,2-dimethyl-propionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pivaloyl chloride | HCID 62493 | — |
| Reactant | (4-Chloro-3-nitrophenyl)methanamine | HCID 18796740 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(4-Chloro-3-nitrobenzyl)-2,2-dimethyl-propionamide | HCID 66765017 | — |
Reaction Steps
TEA (8.00 mL, 57.5 mmol) followed by pivaloyl chloride (2.80 mL, 22.8 mmol) in THF (25 mL) are added to 4-chloro-3-nitrobenzylamine (5.00 g) in THF (100 mL). The reaction mixture is diluted with THF and stirred at rt for 1.5 h. The mixture is filtered and washed and the filtrate is concentrated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586604B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-82f6152cfeb04c0cbbad98eea7d5d7ae |
| Source note | uspto-grants-2013_11 |