Thionyl Chloride → HCID 178521146, compound

HRID 2042813Notes

Reaction equation

HRID 2042813 reaction equation
[F:1][C:2]([F:13])([F:12])[C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9](O)=[O:10])[CH2:5][CH2:4]1.S(Cl)([Cl:16])=O>>[F:1][C:2]([F:13])([F:12])[C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9]([Cl:16])=[O:10])[CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 178525710HCID 178525710, compound

Product 1

HCID 178521146HCID 178521146, compound

Procedure

trans-4-Trifluoromethyl-cyclohexanecarboxylic acid (2.0 g, 10.2 mmol) is stirred in thionyl chloride (30 mL) for 1 h at reflux. The reaction mixture is concentrated and used directly in the next step without further purification.

Workup

  1. temperatureat reflux
  2. concentrationThe reaction mixture is concentrated
  3. customused directly in the next step without further purification

Sources & evidence

ORD record
ord-b2d469e03cd04b0c9d6aca5dca3aa72b
Source dataset
uspto-grants-2013_11
Patent number
US08586604B2

Reaction notes

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