Ammonia → HCID 178513941, compound

HRID 2042814Notes

Reaction equation

HRID 2042814 reaction equation
[F:1][C:2]([F:13])([F:12])[C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9](Cl)=[O:10])[CH2:5][CH2:4]1.[NH3:14]>C1COCC1>[F:1][C:2]([F:13])([F:12])[C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9]([NH2:14])=[O:10])[CH2:5][CH2:4]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 178521146HCID 178521146, compound

Product 1

HCID 178513941HCID 178513941, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of trans-4-trifluoromethyl-cyclohexanecarbonyl chloride (17.3 g, 80.6 mmol) and THF (150 mL) is added dropwise at 15° C. to conc. NH3 (400 mL). The reaction mixture is stirred for 15 min, concentrated and the precipitate is filtered off, washed with water and dried to give the sub-title compound.

Workup

  1. concentrationconcentrated
  2. filtrationthe precipitate is filtered off
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-1b4af688214947f68a2c7e7eea4f5b8f
Source dataset
uspto-grants-2013_11
Patent number
US08586604B2

Reaction notes

Loading…