反应详情

A mixture of trans-4-trifluoromethyl-cyclohexylamine (4.8 g) and TEA (8.3 mL, 59.4 mmol) in THF (150 mL) is stirred for 20 min at rt. 2,6-Dichloro-nicotinoyl chloride (5.0 g, 23.8 mmol) in THF (50 mL) is added dropwise under cooling and the mixture is stirred at rt for 2 h. The reaction mixture is filtered and the filtrate is concentrated. The residue is treated with water, filtered off, washed with water and dried to give the sub-title compound.

1. temperatureunder cooling
2. stirringthe mixture is stirred at rt for 2 h
3. filtrationThe reaction mixture is filtered
4. concentrationthe filtrate is concentrated
5. additionThe residue is treated with water
6. filtrationfiltered off
7. washwashed with water
8. customdried