Nitric Acid → HCID 178523751, compound

HRID 2042816Notes

Reaction equation

HRID 2042816 reaction equation
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([C:6]([NH:8][C@H:9]2[CH2:14][CH2:13][C@H:12]([C:15]([F:18])([F:17])[F:16])[CH2:11][CH2:10]2)=[O:7])=[C:4]([O:21][CH2:22][CH:23]([F:25])[F:24])[N:3]=1.[N+:26]([O-])([OH:28])=[O:27]>OS(O)(=O)=O>[Cl:1][C:2]1[C:20]([N+:26]([O-:28])=[O:27])=[CH:19][C:5]([C:6]([NH:8][C@H:9]2[CH2:14][CH2:13][C@H:12]([C:15]([F:18])([F:17])[F:16])[CH2:11][CH2:10]2)=[O:7])=[C:4]([O:21][CH2:22][CH:23]([F:24])[F:25])[N:3]=1

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 178523749HCID 178523749, compound

Product 1

HCID 178523751HCID 178523751, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

The sub-title compound is prepared from 6-chloro-2-(2,2-difluoro-ethoxy)-N-(trans-4-trifluoromethyl-cyclohexyl)-nicotinamide (7.2 g, 18.6 mmol) and fuming HNO3 (20 mL) in conc. H2SO4 (40 mL) in analogy with example 1c.

Sources & evidence

ORD record
ord-36538725116740bca7b2ab0933889b63
Source dataset
uspto-grants-2013_11
Patent number
US08586604B2

Reaction notes

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