Methylamine → HCID 178482449, compound

Participants

Reaction Steps

Methylamine (2 M in THF; 400 μL, 0.80 mmol) is added to 6-chloro-2-(2-methoxy-ethoxy)-5-nitro-N-(trans-4-trifluoromethyl-cyclohexyl)-nicotinamide (150 mg, 0.35 mmol) in THF (10 mL). After 45 min at rt the reaction mixture is diluted with water, concentrated and filtered. The filtercake is washed with water and dried.

Provenance & Evidence