Methylamine → HCID 178482449, compound

HRID 2042824Notes

Reaction equation

HRID 2042824 reaction equation
[CH3:1][NH2:2].Cl[C:4]1[C:22]([N+:23]([O-:25])=[O:24])=[CH:21][C:7]([C:8]([NH:10][C@H:11]2[CH2:16][CH2:15][C@H:14]([C:17]([F:20])([F:19])[F:18])[CH2:13][CH2:12]2)=[O:9])=[C:6]([O:26][CH2:27][CH2:28][O:29][CH3:30])[N:5]=1>C1COCC1.O>[CH3:30][O:29][CH2:28][CH2:27][O:26][C:6]1[N:5]=[C:4]([NH:2][CH3:1])[C:22]([N+:23]([O-:25])=[O:24])=[CH:21][C:7]=1[C:8]([NH:10][C@H:11]1[CH2:16][CH2:15][C@H:14]([C:17]([F:20])([F:19])[F:18])[CH2:13][CH2:12]1)=[O:9]

Participants

5

Reactant 2

HCID 6329MethylamineHCID 178496181HCID 178496181, compound

Product 1

HCID 178482449HCID 178482449, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

Methylamine (2 M in THF; 400 μL, 0.80 mmol) is added to 6-chloro-2-(2-methoxy-ethoxy)-5-nitro-N-(trans-4-trifluoromethyl-cyclohexyl)-nicotinamide (150 mg, 0.35 mmol) in THF (10 mL). After 45 min at rt the reaction mixture is diluted with water, concentrated and filtered. The filtercake is washed with water and dried.

Workup

  1. concentrationconcentrated
  2. filtrationfiltered
  3. washThe filtercake is washed with water
  4. customdried

Sources & evidence

ORD record
ord-7c25da5ce18342c590f3839c9b30abac
Source dataset
uspto-grants-2013_11
Patent number
US08586604B2

Reaction notes

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