Methanol → HCID 178482448, compound

HRID 2042825Notes

Reaction equation

HRID 2042825 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[N:24]=[C:23]([NH:25][CH3:26])[C:22]([N+:27]([O-])=O)=[CH:21][C:7]=1[C:8]([NH:10][C@H:11]1[CH2:16][CH2:15][C@H:14]([C:17]([F:20])([F:19])[F:18])[CH2:13][CH2:12]1)=[O:9].CO>[Ni].C1COCC1>[NH2:27][C:22]1[C:23]([NH:25][CH3:26])=[N:24][C:6]([O:5][CH2:4][CH2:3][O:2][CH3:1])=[C:7]([CH:21]=1)[C:8]([NH:10][C@H:11]1[CH2:12][CH2:13][C@H:14]([C:17]([F:19])([F:18])[F:20])[CH2:15][CH2:16]1)=[O:9]

Participants

5

Reactant 2

HCID 887MethanolHCID 178482449HCID 178482449, compound

Product 1

HCID 178482448HCID 178482448, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 2-(2-methoxy-ethoxy)-6-methylamino-5-nitro-N-(trans-4-trifluoromethyl-cyclohexyl)-nicotinamide (170 mg, 0.40 mmol), Ra—Ni (50 mg), MeOH (5 mL) and THF (15 mL) is stirred at rt for 2 h under a hydrogen atmosphere (3.0 bar). The catalyst is removed by filtration and the filtrate is concentrated.

Workup

  1. customThe catalyst is removed by filtration
  2. concentrationthe filtrate is concentrated

Sources & evidence

ORD record
ord-2d90e8a468604c76bec2378688b24c10
Source dataset
uspto-grants-2013_11
Patent number
US08586604B2

Reaction notes

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