HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 178508979, compound → HCID 178507778, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 178508979 | HCID 178508979 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178507778 | HCID 178507778 | — |
Reaction Steps
A mixture of 6-amino-2-(2,2-difluoro-ethoxy)-5-nitro-N-(trans-4-trifluoromethyl-cyclohexyl)-nicotinamide (250 mg, 0.61 mmol), Ra—Ni (30 mg) and THF (10 mL) is stirred at rt for 2 h under a hydrogen atmosphere (3.0 bar). The catalyst is removed by filtration and the filtrate is concentrated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586604B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-493cf41805d64f26ba1c36752b416c0f |
| Source note | uspto-grants-2013_11 |