HCID 178508979, compound → HCID 178507778, compound

HRID 2042826Notes

Reaction equation

HRID 2042826 reaction equation
[NH2:1][C:2]1[C:20]([N+:21]([O-])=O)=[CH:19][C:5]([C:6]([NH:8][C@H:9]2[CH2:14][CH2:13][C@H:12]([C:15]([F:18])([F:17])[F:16])[CH2:11][CH2:10]2)=[O:7])=[C:4]([O:24][CH2:25][CH:26]([F:28])[F:27])[N:3]=1>[Ni].C1COCC1>[NH2:21][C:20]1[C:2]([NH2:1])=[N:3][C:4]([O:24][CH2:25][CH:26]([F:27])[F:28])=[C:5]([CH:19]=1)[C:6]([NH:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([C:15]([F:17])([F:16])[F:18])[CH2:11][CH2:10]1)=[O:7]

Participants

4

Reactant 1

HCID 178508979HCID 178508979, compound

Product 1

HCID 178507778HCID 178507778, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 6-amino-2-(2,2-difluoro-ethoxy)-5-nitro-N-(trans-4-trifluoromethyl-cyclohexyl)-nicotinamide (250 mg, 0.61 mmol), Ra—Ni (30 mg) and THF (10 mL) is stirred at rt for 2 h under a hydrogen atmosphere (3.0 bar). The catalyst is removed by filtration and the filtrate is concentrated.

Workup

  1. customThe catalyst is removed by filtration
  2. concentrationthe filtrate is concentrated

Sources & evidence

ORD record
ord-493cf41805d64f26ba1c36752b416c0f
Source dataset
uspto-grants-2013_11
Patent number
US08586604B2

Reaction notes

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