HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 178482443, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | HCID 178482444 | HCID 178482444 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178482443 | HCID 178482443 | — |
Reaction Steps
A mixture of 2-(2-fluoro-ethoxy)-6-methylamino-5-nitro-N-(trans-4-trifluoromethyl-cyclohexyl)-nicotinamide (105 mg, 0.26 mmol), Ra—Ni (25 mg), MeOH (5 mL) and THF (10 mL) is stirred at rt for 2.5 h under a hydrogen atmosphere (3.0 bar). The catalyst is removed by filtration and the filtrate is concentrated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586604B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-739d91f3952442538b4e0629c8087db8 |
| Source note | uspto-grants-2013_11 |