Methanol → HCID 178482443, compound

HRID 2042830Notes

Reaction equation

HRID 2042830 reaction equation
[F:1][CH2:2][CH2:3][O:4][C:5]1[N:23]=[C:22]([NH:24][CH3:25])[C:21]([N+:26]([O-])=O)=[CH:20][C:6]=1[C:7]([NH:9][C@H:10]1[CH2:15][CH2:14][C@H:13]([C:16]([F:19])([F:18])[F:17])[CH2:12][CH2:11]1)=[O:8].CO>[Ni].C1COCC1>[NH2:26][C:21]1[C:22]([NH:24][CH3:25])=[N:23][C:5]([O:4][CH2:3][CH2:2][F:1])=[C:6]([CH:20]=1)[C:7]([NH:9][C@H:10]1[CH2:15][CH2:14][C@H:13]([C:16]([F:18])([F:17])[F:19])[CH2:12][CH2:11]1)=[O:8]

Participants

5

Reactant 2

HCID 887MethanolHCID 178482444HCID 178482444, compound

Product 1

HCID 178482443HCID 178482443, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 2-(2-fluoro-ethoxy)-6-methylamino-5-nitro-N-(trans-4-trifluoromethyl-cyclohexyl)-nicotinamide (105 mg, 0.26 mmol), Ra—Ni (25 mg), MeOH (5 mL) and THF (10 mL) is stirred at rt for 2.5 h under a hydrogen atmosphere (3.0 bar). The catalyst is removed by filtration and the filtrate is concentrated.

Workup

  1. customThe catalyst is removed by filtration
  2. concentrationthe filtrate is concentrated

Sources & evidence

ORD record
ord-739d91f3952442538b4e0629c8087db8
Source dataset
uspto-grants-2013_11
Patent number
US08586604B2

Reaction notes

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