Diisopropylcarbodiimide → HCID 178481221, compound

HRID 2042834Notes

Reaction equation

HRID 2042834 reaction equation
[Cl:1][C:2]1[C:15]([N:16]=[C:17]=S)=[C:14]([Cl:19])[CH:13]=[CH:12][C:3]=1[CH2:4][NH:5][C:6](=[O:11])[C:7]([CH3:10])([CH3:9])[CH3:8].[NH2:20][C:21]1[C:22]([NH:45][CH3:46])=[N:23][C:24]([O:40][CH2:41][CH:42]([F:44])[F:43])=[C:25]([CH:39]=1)[C:26]([NH:28][C@H:29]1[CH2:34][CH2:33][C@H:32]([C:35]([F:38])([F:37])[F:36])[CH2:31][CH2:30]1)=[O:27].CC(C)N=C=NC(C)C>>[Cl:1][C:2]1[C:15]([NH:16][C:17]2[N:45]([CH3:46])[C:22]3=[N:23][C:24]([O:40][CH2:41][CH:42]([F:44])[F:43])=[C:25]([C:26](=[O:27])[NH:28][C@H:29]4[CH2:30][CH2:31][C@H:32]([C:35]([F:37])([F:36])[F:38])[CH2:33][CH2:34]4)[CH:39]=[C:21]3[N:20]=2)=[C:14]([Cl:19])[CH:13]=[CH:12][C:3]=1[CH2:4][NH:5][C:6](=[O:11])[C:7]([CH3:10])([CH3:9])[CH3:8]

Participants

4

Reactant 3

HCID 12734DiisopropylcarbodiimideHCID 56840192N-[(2,4-dichloro-3-isothiocyanatophenyl)methyl]-2,2-dimethylpropanamideHCID 178482445HCID 178482445, compound

Product 1

HCID 178481221HCID 178481221, compound

Procedure

The title compound is prepared from N-(2,4-dichloro-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamide (120 mg, 0.38 mmol) and 5-amino-2-(2,2-difluoro-ethoxy)-N-(trans-4-trifluoromethyl-cyclohexyl)-6-methylamino-nicotinamide (150 mg, 0.38 mmol) with DIC in analogy to examples 8a/8b.

Sources & evidence

ORD record
ord-f4b01ee3c0904c2a8f16751dec39be32
Source dataset
uspto-grants-2013_11
Patent number
US08586604B2

Reaction notes

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