反应详情

温度

110 °C

To a solution of cyanide 42 (3.0 g, 4.25 mmol) in EtOH/H2O (20 mL/20 mL) was added NaOH (20.5 g, 423 mmol). The mixture was stirred at 110° C. for 15 hours. The mixture was cooled to room temperature and evaporated in vacuo to remove EtOH. The residue was diluted with H2O, cooled to 0° C. and acidified with c-HCl solution. The titled compound 43 was precipitated as a solid, dissolved with EtOAc and extracted. The organic layer was dried over anhydrous MgSO4, filtered and concentrated in vacuo to provide the titled compound 43 (2.89 g, 99%).

1. temperatureThe mixture was cooled to room temperature
2. customevaporated in vacuo
3. customto remove EtOH
4. additionThe residue was diluted with H2O
5. temperaturecooled to 0° C.
6. customThe titled compound 43 was precipitated as a solid
7. dissolutiondissolved with EtOAc
8. extractionextracted
9. dry with materialThe organic layer was dried over anhydrous MgSO4
10. filtrationfiltered
11. concentrationconcentrated in vacuo