Sodium Hydroxide → HCID 86680888, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of cyanide 42 (3.0 g, 4.25 mmol) in EtOH/H2O (20 mL/20 mL) was added NaOH (20.5 g, 423 mmol). The mixture was stirred at 110° C. for 15 hours. The mixture was cooled to room temperature and evaporated in vacuo to remove EtOH. The residue was diluted with H2O, cooled to 0° C. and acidified with c-HCl solution. The titled compound 43 was precipitated as a solid, dissolved with EtOAc and extracted. The organic layer was dried over anhydrous MgSO4, filtered and concentrated in vacuo to provide the titled compound 43 (2.89 g, 99%).

Provenance & Evidence