Hydrochloric Acid → 2-Amino-1-(3-thienyl)ethanone hydrochloride
Reaction equation
[O:1]=[C:2]([C:12]1[CH:16]=[CH:15][S:14][CH:13]=1)[CH2:3][NH:4]C(=O)OC(C)(C)C.[ClH:17]>CCOCC>[ClH:17].[NH2:4][CH2:3][C:2]([C:12]1[CH:16]=[CH:15][S:14][CH:13]=1)=[O:1]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
To a mixture of tert-butyl 2-oxo-2-(thiophen-3-yl)ethylcarbamate (776 mg, 3.21 mmol) in Et2O (3 mL) was added a HCl solution (4.0 M in dioxane, 6 mL) at 0° C. After stirring at 0° C. for 10 min, the resulting mixture was allowed warmed up to room temperature and stirred for 2 h. The reaction mixture was evaporated under vacuum to provide the titled compound (570 mg, quantitative) as a white solid. MH+142.
Workup
- temperaturethe resulting mixture was allowed warmed up to room temperature
- stirringstirred for 2 h
- customThe reaction mixture was evaporated under vacuum
Sources & evidence
- ORD record
- ord-796cdd55deca459e92e656de905d858e
- Source dataset
- uspto-grants-2013_11
- Patent number
- US08586550B2
Reaction notes
Loading…