Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Alpha-D-Glucose | HCID 79025 | — |
| Reactant | Methyl 2-(2,3-dihydro-1H-indol-3-yl)acetate | HCID 11816349 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 67995230 | HCID 67995230 | 88% |
Reaction Steps
To a solution of indoline 75 (8.5 g, 44.2 mmol) in MeOH (150 mL) was added α-D-glucose (27 g, 146 mmol) at room temperature. The mixture was stirred at 70° C. for 60 h, cooled to room temperature and concentrated in vacuo to remove solvent. The residue was purified by silica column chromatography to provide the titled compound 76 (13.7 g, 88%). MH+354.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08586550B2 |
|---|
| Source dataset | uspto-grants-2013_11 |
|---|
| ORD ID | ord-9a06d9b7ed3743de99c213af9790aea7 |
|---|
| Source note | uspto-grants-2013_11 |
|---|
