HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → [1-(3,7-Dimethylxanthin-1-yl)methyl]dimethylphosphine Oxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Phosphine oxide, (chloromethyl)dimethyl- | HCID 74224 | — |
| Reactant | 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione, sodium salt | HCID 66973603 | — |
| Product | [1-(3,7-Dimethylxanthin-1-yl)methyl]dimethylphosphine Oxide | HCID 19689229 | — |
Reaction Steps
A solution of 20.2 g (0.1 mol) of theophylline sodium salt in 400 ml of DMF was heated at 130° C. for 3 hours with 12.7 g of chloromethyldimethyl-phosphine oxide. The solution was filtered, the solvent was evaporated and the residue was taken up in methanol. The precipitate was filtered off and dried to constant weight under reduced pressure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05728686 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-3604df54e33345c3b923bde3a99dbbb6 |
| Source note | uspto-grants-1998_03 |