Methyl 3-(4-((3-hydroxyphenyl)ethynyl)phenyl)propanoate → HCID 58319127, compound

HRID 2043019Notes

Reaction equation

HRID 2043019 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][C:18]([O:20]C)=[O:19])=[CH:12][CH:11]=2)[CH:5]=[CH:6][CH:7]=1>CCOC(C)=O>[OH:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH:11]=[CH:12][C:13]([CH2:16][CH2:17][C:18]([OH:20])=[O:19])=[CH:14][CH:15]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 58319096Methyl 3-(4-((3-hydroxyphenyl)ethynyl)phenyl)propanoate

Product 1

HCID 58319127HCID 58319127, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound was prepared from methyl 3-(4-((3-hydroxyphenyl)ethynyl)phenyl)propanoate (54 mg, 0.19 mmol) according to the general procedure II to a white solid. Rf=0.02 (EtOAc:PE); 1H NMR ((CD3)2CO): δ 7.45 (d, J=7.4 Hz, 2H) 7.31 (d, J=7.6 Hz, 2H) 7.25-7.20 (m, 1H) 7.00 (s, 2H) 6.89-6.86 (m, 1H) 2.95 (t, J=7.7 Hz, 2H) 2.64 (t, J=7.3 Hz, 2H); 13C NMR ((CD3)2CO): δ 173.8, 158.3, 142.8, 132.4, 130.6, 129.5, 125.1, 123.7, 121.8, 118.8, 116.8, 89.7, 89.6, 35.5, 31.4.

Sources & evidence

ORD record
ord-d66a2eae13954c039c9a6352e8203d8d
Source dataset
uspto-grants-2013_11
Patent number
US08586607B2

Reaction notes

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