反应详情

376 mg (1 mmol) of 4-(2-(5-chloro-2-methoxybenzamido)ethyl)piperidine-1-sulfonamide and 652 mg (2.0 mmol) of cesium carbonate were heated in 5 ml of N-methyl-2-pyrrolidone with 0.3 ml (2 mmol) of cyclohexyl isothiocyanate at 80° C. for 10 minutes. The reaction mixture was poured onto ice/2 M hydrochloric acid, and the precipitated solid was filtered off with suction, washed with water until neutral, dissolved in methanol, filtered after addition of activated carbon and crystallized using diethyl ether. 230 mg (45%) of the title compound were obtained as a colorless solid.

1. additionThe reaction mixture was poured onto ice/2 M hydrochloric acid
2. filtrationthe precipitated solid was filtered off with suction
3. washwashed with water until neutral,
4. dissolutiondissolved in methanol
5. filtrationfiltered
6. additionafter addition of activated carbon
7. customcrystallized