反应详情

376 mg (1 mmol) of 4-(2-(5-chloro-2-methoxybenzamido)ethyl)piperidine-1-sulfonamide and 80 mg (2 mmol) of sodium hydroxide were heated in 5 ml of N-methyl-2-pyrrolidone with 180 mg (1 mmol) of N-methyltrichloroacetamide at 80° C. for 10 minutes. The reaction mixture was poured onto ice/2 M hydrochloric acid, and the precipitated solid was filtered off with suction and washed with water until neutral. Purification by chromatography (silica gel; toluene/ethanol/ethyl acetate 8/1/1) resulted in 25 mg (6%) of the title compound as a colorless solid.

1. additionThe reaction mixture was poured onto ice/2 M hydrochloric acid
2. filtrationthe precipitated solid was filtered off with suction
3. washwashed with water until neutral
4. customPurification by chromatography (silica gel; toluene/ethanol/ethyl acetate 8/1/1)