反应详情

A mixture of 4-butoxy-N-[4-(3-oxopyrrolidin-1-yl)phenyl]benzamide (70 mg), ethanolamine (12 mg), potassium carbonate (27 mg) and dichloromethane (3 ml) was stirred for 48 hours, and then acetyl chloride (16 mg) was added. After 20 hours, the mixture was diluted with dichloromethane, washed with water, dried over magnesium sulfate and concentrated. The residue was purified by preparative HPLC. The product with the molecular weight of 437.54 (C25H31N3O4); MS (ESI): 438 (M+H+) was obtained in this way.

1. waitAfter 20 hours
2. washwashed with water
3. dry with materialdried over magnesium sulfate
4. concentrationconcentrated
5. customThe residue was purified by preparative HPLC
6. customMS (ESI): 438 (M+H+) was obtained in this way