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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 204332Generated: October 30, 2026

Toluene → Methyl 2-[1-[1-[tert-butyl(diphenyl)silyl]oxybutan-2-yl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-2-oxopiperidin-3-yl]propanoate

https://huagongshe.com/reaction/204332

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTolueneHCID 1140—
ReactantMethyl iodideHCID 6328—
ReactantTetrahydrofuranHCID 8028—
ReactantHexamethylphosphoramideHCID 12679—
ReactantLithium ionHCID 28486—
ReactantNpc316347HCID 3280088—
ReactantMethyl 2-[1-[1-[tert-butyl(diphenyl)silyl]oxybutan-2-yl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-2-oxopiperidin-3-yl]acetateHCID 76834741—
ProductMethyl 2-[1-[1-[tert-butyl(diphenyl)silyl]oxybutan-2-yl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-2-oxopiperidin-3-yl]propanoateHCID 76834359—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (6/10)
ORD IDord-58bdceafb5c04ac9a08f0ed3d4a85a66
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (6/10)