Toluene → Methyl 2-[1-[1-[tert-butyl(diphenyl)silyl]oxybutan-2-yl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-2-oxopiperidin-3-yl]propanoate
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[Si:5]([O:6][CH2:7][CH:8]([CH2:9][CH3:10])[N:11]1[C:12](=[O:36])[CH:13]([CH2:31][C:32](=[O:33])[O:34][CH3:35])[CH2:14][CH:15]([c:24]2[cH:25][c:26]([Cl:30])[cH:27][cH:28][cH:29]2)[CH:16]1[c:17]1[cH:18][cH:19][c:20]([Cl:23])[cH:21][cH:22]1)([c:37]1[cH:38][cH:39][cH:40][cH:41][cH:42]1)[c:43]1[cH:44][cH:45][cH:46][cH:47][cH:48]1.[CH2:72]1[O:73][CH2:74][CH2:75][CH2:76]1.[CH3:49][N:50]([CH3:51])[P:52]([N:53]([CH3:54])[CH3:55])([N:56]([CH3:57])[CH3:58])=[O:59].[CH3:61][Si:62]([N-:63][Si:64]([CH3:65])([CH3:66])[CH3:67])([CH3:68])[CH3:69].[CH3:77][c:78]1[cH:79][cH:80][cH:81][cH:82][cH:83]1.[I:70][CH3:71].[Li+:60]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[Si:5]([O:6][CH2:7][CH:8]([CH2:9][CH3:10])[N:11]1[C:12](=[O:36])[CH:13]([CH:31]([C:32](=[O:33])[O:34][CH3:35])[CH3:49])[CH2:14][CH:15]([c:24]2[cH:25][c:26]([Cl:30])[cH:27][cH:28][cH:29]2)[CH:16]1[c:17]1[cH:18][cH:19][c:20]([Cl:23])[cH:21][cH:22]1)([c:37]1[cH:38][cH:39][cH:40][cH:41][cH:42]1)[c:43]1[cH:44][cH:45][cH:46][cH:47][cH:48]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-58bdceafb5c04ac9a08f0ed3d4a85a66
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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