Hydrochloric Acid → 4-(Hydroxymethyl)-4-piperidinol hydrochloride

HRID 2043443노트

반응식

HRID 2043443 반응식
C([N:8]1[CH2:13][CH2:12][C:11]([CH2:15][OH:16])([OH:14])[CH2:10][CH2:9]1)C1C=CC=CC=1.[ClH:17]>C(O)C.[C].[Pd]>[ClH:17].[OH:16][CH2:15][C:11]1([OH:14])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 140253361-Benzyl-4-(hydroxymethyl)piperidin-4-ol

생성물 1

HCID 227444724-(Hydroxymethyl)-4-piperidinol hydrochloride

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매

실험 절차

500 mg of 1-benzyl-4-(hydroxymethyl)piperidin-4-ol (synthesized according to the method described in J. Med. Chem., 1988, 486-491) was dissolved in 10 ml of ethanol, 300 mg of 10% palladium carbon and 0.38 ml of concentrated hydrochloric acid were added thereto, and the mixture was subjected to hydrogenation at room temperature overnight. The reaction mixture was filtrated to remove precipitates, the precipitates were washed with ethanol and water, and the filtrate was concentrated under reduced pressure. The obtained residue was turned into powder by adding diethylether to obtain 374 mg of the objective compound as a white powder.

후처리

  1. filtrationThe reaction mixture was filtrated
  2. customto remove
  3. customprecipitates
  4. washthe precipitates were washed with ethanol and water
  5. concentrationthe filtrate was concentrated under reduced pressure
  6. additionby adding diethylether

출처 및 근거

ORD 기록
ord-4e510fa01fb14463a48738b2380e3fd0
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08586591B2

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