Ammonia methanol → HCID 67007513, compound

HRID 2043477Notes

Reaction equation

HRID 2043477 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([NH:10][C:11]2[CH:16]=[C:15]([NH2:17])[CH:14]=[C:13]([NH:18][C:19]3[CH:24]=[N:23][CH:22]=[CH:21][N:20]=3)[N:12]=2)[CH3:9])=[CH:4][CH:3]=1.[CH3:25][OH:26].[NH3:27]>C(Cl)Cl>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([NH:10][C:11]2[CH:16]=[C:15]([NH:17][C:25]([NH2:27])=[O:26])[CH:14]=[C:13]([NH:18][C:19]3[CH:24]=[N:23][CH:22]=[CH:21][N:20]=3)[N:12]=2)[CH3:9])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 21705897Ammonia methanolHCID 86659409HCID 86659409, compound

Product 1

HCID 67007513HCID 67007513, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

50 mg of (S)—N2-[1-(4-fluorophenyl)ethyl]-N6-(pyrazin-2-yl)pyridine-2,4,6-triamine was dissolved in 2 ml of methylene chloride, and 49 mg of N,N′-carbonyldiimidazole was added thereto, and the mixture was stirred at room temperature overnight. A saturated ammonia methanol solution was added to the reaction mixture, and the mixture was stirred at room temperature overnight. The solvent of the reaction solution was distilled off under reduced pressure, and the obtained residue was purified by silica gel column chromatography to obtain 23 mg of the objective compound as pale yellow powder.

Workup

  1. stirringthe mixture was stirred at room temperature overnight
  2. distillationThe solvent of the reaction solution was distilled off under reduced pressure
  3. customthe obtained residue was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-336167af634f4765b265c065f5dac7d4
Source dataset
uspto-grants-2013_11
Patent number
US08586591B2

Reaction notes

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