Triethylamine → 1-{[(3-Nitropyridin-2-yl)amino]methyl}-4-propylpyrrolidin-2-one

HRID 2043604Notes

Reaction equation

HRID 2043604 reaction equation
[NH2:1][CH2:2][N:3]1[CH2:7][CH:6]([CH2:8][CH2:9][CH3:10])[CH2:5][C:4]1=[O:11].Cl[C:13]1[C:18]([N+:19]([O-:21])=[O:20])=[CH:17][CH:16]=[CH:15][N:14]=1.C(N(CC)CC)C>O1CCOCC1>[N+:19]([C:18]1[C:13]([NH:1][CH2:2][N:3]2[CH2:7][CH:6]([CH2:8][CH2:9][CH3:10])[CH2:5][C:4]2=[O:11])=[N:14][CH:15]=[CH:16][CH:17]=1)([O-:21])=[O:20]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 796132-Chloro-3-nitropyridineHCID 536292181-(Aminomethyl)-4-propylpyrrolidin-2-one

Product 1

HCID 577430171-{[(3-Nitropyridin-2-yl)amino]methyl}-4-propylpyrrolidin-2-oneYield 53%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 1-(aminomethyl)-4-propylpyrrolidin-2-one x76 (1 eq, 17.09 mmol, 2.67 g), 2-chloro-3-nitropyridine (1 eq, 17.09 mmol, 2.709 g) and triethylamine (1.1 eq, 18.8 mmol, 1.902 g, 2.62 ml) in dioxane (20 ml) is refluxed 48 h. After cooling, the crude mixture is filtrated and the dioxane is distilled under vacuum. The residue is purified by preparative chromatography to afford 2.5 g of 1-{[(3-nitropyridin-2-yl)amino]methyl}-4-propylpyrrolidin-2-one x77.

Workup

  1. temperatureis refluxed 48 h
  2. temperatureAfter cooling
  3. filtrationthe crude mixture is filtrated
  4. distillationthe dioxane is distilled under vacuum
  5. customThe residue is purified by preparative chromatography

Sources & evidence

ORD record
ord-2c18f4d49ef0469f9562424d62945848
Source dataset
uspto-grants-2013_11
Patent number
US08586623B2

Reaction notes

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