Hydrochloric Acid → HCID 67460128, compound

HRID 2043758Notes

Reaction equation

HRID 2043758 reaction equation
[CH3:1][C:2]1[N:6]([CH2:7][C:8]([N:10]2[CH2:15][CH2:14][CH:13]([C:16]([O:18]CC)=[O:17])[CH2:12][CH2:11]2)=[O:9])[N:5]=[C:4]([C:21]([F:24])([F:23])[F:22])[CH:3]=1.[OH-].[Na+].Cl>CO>[CH3:1][C:2]1[N:6]([CH2:7][C:8]([N:10]2[CH2:15][CH2:14][CH:13]([C:16]([OH:18])=[O:17])[CH2:12][CH2:11]2)=[O:9])[N:5]=[C:4]([C:21]([F:24])([F:22])[F:23])[CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67464119HCID 67464119, compound2×

Product 1

HCID 67460128HCID 67460128, compoundYield 68%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of ethyl 1-[[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinylcarboxylate (3.6 g, 10.36 mmol) (i.e. the product of Example 17, Step C) in methanol (10 mL) was treated with 1 M sodium hydroxide aqueous solution (15.54 mL, 15.54 mmol) at 0° C. The reaction mixture was stirred at room temperature for 2 h and then 1 M hydrochloric acid (15.54 mL, 15.54 mmol) was added, and most of methanol was evaporated in vacuo leaving white crystals. The crystals were filtered and dried to give 2.25 g of the title compound as a white solid.

Workup

  1. custommost of methanol was evaporated in vacuo
  2. customleaving white crystals
  3. filtrationThe crystals were filtered
  4. customdried

Sources & evidence

ORD record
ord-85f0998ce7794b428d75d7ac1ec8ac55
Source dataset
uspto-grants-2013_11
Patent number
US08586611B2

Reaction notes

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