Hydrochloric Acid → 922516-38-9

HRID 2043762Notes

Reaction equation

HRID 2043762 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:9]=[CH:8][N:7]([CH:10]2[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]2)[N:6]=1)=[O:4].[ClH:23]>C(OCC)C>[ClH:23].[NH:13]1[CH2:14][CH2:15][CH:10]([N:7]2[CH:8]=[CH:9][C:5]([C:3]([O:2][CH3:1])=[O:4])=[N:6]2)[CH2:11][CH2:12]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 674641231,1-dimethylethyl 4-[3-(methoxycarbonyl)-1H-pyrazol-1-yl]-1-piperidinecarboxylate2×

Product 1

HCID 67461532922516-38-9

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a solution of 1,1-dimethylethyl 4-[3-(methoxycarbonyl)-1H-pyrazol-1-yl]-1-piperidinecarboxylate (300 mg, 0.97 mmol) (i.e. the product of Example 18, Step B) in 5 mL of diethyl ether was added a 2 M solution of hydrogen chloride in ether (4.85 mL, 9.7 mmol), and the reaction mixture was stirred for 5 h at room temperature. The reaction mixture was evaporated in vacuo, the resulting residue was dissolved in methanol and concentrated in vacuo. The residue was dried in high vacuum to give 200 mg of the title compound as a white solid.

Workup

  1. customThe reaction mixture was evaporated in vacuo
  2. dissolutionthe resulting residue was dissolved in methanol
  3. concentrationconcentrated in vacuo
  4. customThe residue was dried in high vacuum

Sources & evidence

ORD record
ord-38ab3ed50a94420386ba56960e957749
Source dataset
uspto-grants-2013_11
Patent number
US08586611B2

Reaction notes

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