Hydrochloric Acid → Ethyl 2-(1-piperazinyl)-4-thiazolecarboxylate monohydrochloride

HRID 2043780Notes

Reaction equation

HRID 2043780 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[C:8]([N:11]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]2)[S:9][CH:10]=1)=[O:5])[CH3:2].[ClH:24]>ClCCl.C(OCC)C>[ClH:24].[N:11]1([C:8]2[S:9][CH:10]=[C:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[N:7]=2)[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 53418800Ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-YL)thiazole-4-carboxylate2×

Product 1

HCID 67463024Ethyl 2-(1-piperazinyl)-4-thiazolecarboxylate monohydrochloride

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

A solution of 1,1-dimethylethyl 4-[4-(ethoxycarbonyl)-2-thiazolyl]-1-piperazinecarboxylate (1.0 g, 3.4 mmol) (i.e. the product of Example 30, Step A) in 10 mL of dichloromethane was treated with 2 M hydrogen chloride in diethyl ether (10 mL) and the reaction mixture was stirred at room temperature for 16 h. The resulting mixture was evaporated in vacuo to give 1.0 g of the title compound as a white solid. This compound was of sufficient purity to use in subsequent reactions.

Workup

  1. customThe resulting mixture was evaporated in vacuo

Sources & evidence

ORD record
ord-2284b91b1dd9469db34ad02a6e523291
Source dataset
uspto-grants-2013_11
Patent number
US08586611B2

Reaction notes

Loading…