Sodium Hydroxide → HCID 67462546, compound

HRID 2043790Notes

Reaction equation

HRID 2043790 reaction equation
[CH3:1][C:2]1[N:6]([CH2:7][C:8]([N:10]2[CH2:15][CH2:14][CH:13]([N:16]3N=[C:19]([C:21]([O:23]CC)=[O:22])[CH:18]=[N:17]3)[CH2:12][CH2:11]2)=[O:9])[N:5]=[C:4]([C:26]([F:29])([F:28])[F:27])[CH:3]=1.[CH3:30]N([C@H]1C2C(=CC=CC=2)CCC1)C(C1C=NN(C2CCN(C(=O)CN3C(C)=CC(C(F)(F)F)=N3)CC2)C=1)=O.[OH-].[Na+]>>[CH3:1][C:2]1[N:6]([CH2:7][C:8]([N:10]2[CH2:11][CH2:12][CH:13]([N:16]3[CH:30]=[C:19]([C:21]([OH:23])=[O:22])[CH:18]=[N:17]3)[CH2:14][CH2:15]2)=[O:9])[N:5]=[C:4]([C:26]([F:29])([F:28])[F:27])[CH:3]=1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 66795812HCID 66795812, compoundHCID 67460233HCID 67460233, compound

Product 1

HCID 67462546HCID 67462546, compound

Procedure

By a procedure analogous to that of Example 32 Step C, ethyl 2-[1-[[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-2H-1,2,3-triazole-4-carboxylate (0.24 g, 0.58 mmol) (i.e. the product of Example 33, Step B) was hydrolyzed with 1 N aqueous sodium hydroxide (1.2 mL, 1.2 mmol) to afford 0.125 g of the title compound as a white solid.

Sources & evidence

ORD record
ord-6dd1c28dba7344818bbc79db281af44b
Source dataset
uspto-grants-2013_11
Patent number
US08586611B2

Reaction notes

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