HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 66795812, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | (R)-N-Methyl-1,2,3,4-tetrahydronaphthalen-1-amine | HCID 7128544 | — |
| Reactant | HCID 67462546 | HCID 67462546 | — |
| Product | HCID 66795812 | HCID 66795812 | 65.8% |
Reaction Steps
By a procedure analogous to that of Example 32, Step D, 1-[1-[[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidin yl]-1H-pyrazole-4-carboxylic acid (0.081 g, 0.21 mmol) (i.e. the product of Example 33, Step C) was reacted with oxalyl chloride (0.05 mL) and the resulting product was reacted with (R)—N-methyl-1,2,3,4-tetrahydronaphthalen-1-ylamine (0.038 g, 0.23 mmol) and triethylamine (0.038 mL, 0.27 mmol) to afford 0.073 g of the title compound, a compound of the present invention as an oil after purification by medium pressure liquid chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586611B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-605f55cccfd74fef8a82b377036a3ee5 |
| Source note | uspto-grants-2013_11 |