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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2043791Generated: October 29, 2026

Triethylamine → HCID 66795812, compound

https://huagongshe.com/reaction/2043791

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTriethylamineHCID 8471—
ReactantOxalyl chlorideHCID 65578—
Reactant(R)-N-Methyl-1,2,3,4-tetrahydronaphthalen-1-amineHCID 7128544—
ReactantHCID 67462546HCID 67462546—
ProductHCID 66795812HCID 6679581265.8%

Reaction Steps

By a procedure analogous to that of Example 32, Step D, 1-[1-[[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidin yl]-1H-pyrazole-4-carboxylic acid (0.081 g, 0.21 mmol) (i.e. the product of Example 33, Step C) was reacted with oxalyl chloride (0.05 mL) and the resulting product was reacted with (R)—N-methyl-1,2,3,4-tetrahydronaphthalen-1-ylamine (0.038 g, 0.23 mmol) and triethylamine (0.038 mL, 0.27 mmol) to afford 0.073 g of the title compound, a compound of the present invention as an oil after purification by medium pressure liquid chromatography.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08586611B2
Source datasetuspto-grants-2013_11
ORD IDord-605f55cccfd74fef8a82b377036a3ee5
Source noteuspto-grants-2013_11