Triethylamine → HCID 66795812, compound

HRID 2043791Notes

Reaction equation

[CH3:1][C:2]1[N:6]([CH2:7][C:8]([N:10]2[CH2:15][CH2:14][CH:13]([N:16]3[CH:20]=[C:19]([C:21]([OH:23])=O)[CH:18]=[N:17]3)[CH2:12][CH2:11]2)=[O:9])[N:5]=[C:4]([C:24]([F:27])([F:26])[F:25])[CH:3]=1.C(Cl)(=O)C(Cl)=O.[CH3:34][NH:35][C@H:36]1[C:45]2[C:40](=[CH:41][CH:42]=[CH:43][CH:44]=2)[CH2:39][CH2:38][CH2:37]1.C(N(CC)CC)C>>[CH3:34][N:35]([C@H:36]1[C:45]2[C:40](=[CH:41][CH:42]=[CH:43][CH:44]=2)[CH2:39][CH2:38][CH2:37]1)[C:21]([C:19]1[CH:18]=[N:17][N:16]([CH:13]2[CH2:14][CH2:15][N:10]([C:8](=[O:9])[CH2:7][N:6]3[C:2]([CH3:1])=[CH:3][C:4]([C:24]([F:25])([F:26])[F:27])=[N:5]3)[CH2:11][CH2:12]2)[CH:20]=1)=[O:23]

Participants

Reactant 4

HCID 8471Triethylamine

HCID 65578Oxalyl chloride

HCID 7128544(R)-N-Methyl-1,2,3,4-tetrahydronaphthalen-1-amine

HCID 67462546HCID 67462546, compound2×

Product 1

HCID 66795812HCID 66795812, compoundYield 65.8%

Procedure

By a procedure analogous to that of Example 32, Step D, 1-[1-[[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidin yl]-1H-pyrazole-4-carboxylic acid (0.081 g, 0.21 mmol) (i.e. the product of Example 33, Step C) was reacted with oxalyl chloride (0.05 mL) and the resulting product was reacted with (R)—N-methyl-1,2,3,4-tetrahydronaphthalen-1-ylamine (0.038 g, 0.23 mmol) and triethylamine (0.038 mL, 0.27 mmol) to afford 0.073 g of the title compound, a compound of the present invention as an oil after purification by medium pressure liquid chromatography.

Sources & evidence

ORD record: ord-605f55cccfd74fef8a82b377036a3ee5
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08586611B2

Reaction notes

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