反应详情

Add sodium borohydride (1.30 g, 34.46 mmol) to 1-fluoro-3-((E)-2-nitro-vinyl)-5-propoxy-benzene (1.94 g, 8.61 mmol) and silica gel (17 g) in chloroform (86 mL) and isopropanol (25 mL) at room temperature in portions over 5 minutes. Stir at room temperature 2 hours and filter. Concentrate the filtrate and dissolve in ethyl acetate. Wash with water and saturated aqueous sodium chloride, dry over magnesium sulfate, filter and concentrate. Purify on 40 g silica gel eluting with 100:0 to 70:30 hexanes:ethyl acetate to give 1.1 g (56.2%) of the desired compound as an oil.

1. filtrationfilter
2. concentrationConcentrate the filtrate
3. dissolutiondissolve in ethyl acetate
4. washWash with water and saturated aqueous sodium chloride
5. dry with materialdry over magnesium sulfate
6. filtrationfilter
7. concentrationconcentrate
8. customPurify on 40 g silica gel eluting with 100:0 to 70:30 hexanes